Producto Fenólicos y sus beneficios:

Hidroxitirosol y Ácido Maslínico

El mundo del olivo y su entorno

UNESCO. unesco.org. http://www.unesco.org/culture/ich/es/RL/00884.

Describing chemical singularity of Spanish protected designations of origin of virgin olive oils in relation to oils from neighbouring areas. Tena, N., et al. 1, 2012, Gra- sas y Aceites, Vol. 63, págs. 26-34.

Estimation of the intake of phenol compounds from virgin olive oil of a population from southern Spain. de la Torre-Robles, A., et al. 9, 2014, Food Additives & Conta- minants: Part A, Vol. 31, págs. 1460–1469.

Postprandial effects of the mediterranean diet on oxidant and antioxidant status in ederly men an women. Pérez-Jimenez, F. et al. 5, 2011, J Am Geriatr Soc, Vol. 59, págs. 938-940.

Fenoles provenientes del olivo

Fregapane, G., et al. Influence of irrigation management and ripening on virgin olive oil quality and composition. [ed.] Victor R. Preedy. Olives and Olive Oil in Health and Disease Prevention. s.l. : Elsevier, 2010, págs. 51-58.

EFSA. Scientific Opinion on the substantiation of health claims related to polyphenols in olive and protection of LDL particles from oxidative damage (ID 1333, 1638, 1639, 1696, 2865), maintenance of normal blood HDL cholesterol concentrations (ID 1639), mainte. 2011.

Hidroxitirosol, características y propiedades

Diener, M. R., et al. The toxicity profile of hydrolyzed aqueous olive pulp extract . [aut. libro] Victor R. Preedy. Olives and olive oil in health and disease prevention. s.l. : Elsevier, 2010, págs. 471-479.

Safety assessment of aqueous olive pulp extract as an antioxidant or antimicrobial agent in foods. Soni, M. G., et al. 2006, Food and Chemical Toxicology, Vol. 44, págs. 903-915.

Toxicological evaluation of pure hydroxytyrosol. Visioli, F., et al. 2013a, Food and Chemical Toxicology, Vol. 55, págs. 498–504. Hydroxytyrosol is not genotoxic in vitro. Visioli, F., et al. 2013b, Pharmacological Research, Vol. 74, págs. 87-93.
Alcohol consumption is associated with high concentrations of urinary hydroxytyrosol. Schöder, H., et al. 2009, American Journal of Clinical Nutrition, págs. 1329- 1335.

Battinelli L., Daniele C., Cristiani M., Bisignano G., Saija A. & Mazzanti G. 2006. In vitro antifungal and anti-elastase activity of some aliphatic aldehydes from Olea europaea L. fruit. Phytomedicine 13, 558-63.

Bisignano G., Tomaino A., Lo Cascio R., Crisafi G., Uccella N. & Saija A. 1999. On the invitro antimicrobial activity of oleuropein and hydroxytyrosol. J Pharm Pharmacol 51, 971- 4.

Botsoglou E., Govaris A., Christaki E. & Botsoglou N. 2010. Effect of dietary olive leaves and/or α-tocopheryl acetate supplementation on microbial growth and lipid oxidation of turkey breast fillets during refrigerated storage. Food Chemistry 121, 17-22.

De la Fuente P., Chamorro P., Moreno M. & Poza M.A. 2004. Propiedades antioxidantes del hidroxitirosol procedente de la hoja de olivo (Olea europaea L.). Revista de Fitoterapia 4, 139-47.

De Pablos L.M., dos Santos M.F., Montero E., Garcia-Granados A., Parra A. & Osuna A.2010a. Anticoccidial activity of maslinic acid against infection with Eimeria tenella inchickens. Parasitol Res 107, 601-4.

De Pablos L.M., Gonzalez G., Rodrigues R., Garcia Granados A., Parra A. & Osuna A.2010b. Action of a pentacyclic triterpenoid, maslinic acid, against Toxoplasma gondii. J NatProd 73, 831-4.

Fernandez-Navarro M., Peragon J., Amores V., De La Higuera M. & Lupianez J.A. 2008.Maslinic acid added to the diet increases growth and protein-turnover rates in the whitemuscle of rainbow trout (Oncorhynchus mykiss). Comp Biochem Physiol C ToxicolPharmacol 147, 158-67.

Capacidad antioxidante del Hidroxitirosol

Chronic hydroxytyrosol feeding modulates glutathione-mediated oxido-reduction pathways in adipose tissue: a nutrigenomic study. Giordano, E., et al., 2014. NutrMetab Cardiovasc Dis. 2014 Oct;24(10):1144-50.

Phenolic compounds and antioxidant capacity of virgin olive oil. Franco, M. N., et al., 2014. Food Chem. 2014 Nov 15;163:289-98.

Benavente-Garcı́ a O., Castillo J., Lorente J., Ortuño A. & Del Rio J.A. 2000. Antioxidant activity of phenolics extracted from Olea europaea L. leaves. Food Chemistry 68, 457-62.

Salud cardiovascular al consumir Hidroxitirosol

González Santiago, M. P. Estudio de los efectos cardiovasculares y la absorción oral del hidroxitirosol en modelos animales y humanos. (Tesis doctoral). 2005.

Protection of LDL from oxidation by olive oil polyphenols is associated with a downregulation of CD40-ligand expression and its downstream products in vivo in hu- mans. Castañer, O., et al. 2012, Am J Clin Nutr. 2012 May;95(5):1238-44.

Effects of hydroxytyrosol-enriched sunflower oil consumption on CVD risk factors. Vázquez-Velasco, M., et al., 2011. Br J Nutr. 2011 May;105(10):1448-52.

Enfermedades oncológicas

Hydroxytyrosol protects against oxidative DNA damage in human breast cells. Warleta, F., et al., 2011. Nutrients. 2011
Oct;3(10):839-57.

Granados Principal, Sergio. Mecanismos moleculares implicados en el tratamiento del cáncer de mama: terapia combinada de citostáticos y compuestos minoritarios del aceite de oliva virgen. 2008.

El Azem de Haro, Nuri. Efecto del hidroxitirosol sobre la cardiotoxicidad producida por doxorubicina. s.l. : Universidad de Granada, 2012.

Inmunomodulador
Olive oil biophenols and women’s health. Fistonić, I., et al. 2012. Med Glas (Zenica). 2012 Feb;9(1):1-9.

Neuroprotector

Cytoprotective effects of olive mill wastewater extract and its main constituent hydroxytyrosol in PC12 cells. Schaffer, S., et al., 2010. Pharmacol Res. 2010 Oct;62(4):322-7.

Hydroxytyrosol-rich olive mill wastewater extract protects brain cells in vitro and ex vivo. Schaffer, S., et al., 2007. J Agric Food Chem. 2007 Jun 27;55(13):5043-9. Role of the inhibition of oxidative stress and inflammatory mediators in the neuroprotective effects of hydroxytyrosol in rat brain slices subjected to hypoxia reoxyge-nation. Cabrerizo, S., et al., 2013. J Nutr Biochem. 2013 Dec;24
(12):2152-7.

Otras propiedades
Antiinflamatorio / Articular / Muscular:

Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis. Silva, S., et al., 2014. J NutrBiochem. 2014 Dec 30. pii: S0955-2863(14)00261-7.